Motif ID: MEF2{A,B,C,D}.p2

Z-value: 1.321


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Dchr1_-_1564705060.883.5e-03Click!
MEF2Achr15_+_100106132-0.801.8e-02Click!
MEF2Bchr19_-_19281090,
chr19_-_19281062
0.782.2e-02Click!
MEF2Cchr5_-_88119604-0.658.3e-02Click!
MEF2BNB-MEF2Bchr19_-_19303222-0.581.3e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_41742666 3.576 NM_002192
INHBA
inhibin, beta A
chr18_+_29027731 3.287 NM_001944
DSG3
desmoglein 3
chr20_+_58251715 2.982 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr10_+_118187381 2.377 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chrX_-_117107700 1.831 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr14_-_105634708 1.725 JAG2
jagged 2
chr14_+_39735871 1.657 CTAGE5
CTAGE family, member 5
chr14_-_61748510 1.527 NM_001017970
TMEM30B
transmembrane protein 30B
chr12_-_28124915 1.452 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr15_+_40531236 1.423 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_-_136847609 1.370 MAP7
microtubule-associated protein 7
chr15_+_40509628 1.331 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr5_-_16509106 1.290 NM_019000
FAM134B
family with sequence similarity 134, member B
chr7_+_18126543 1.271 NM_001204144
HDAC9
histone deacetylase 9
chr1_+_13911966 1.238 NM_001006624
NM_001006625
PDPN

podoplanin

chr17_-_56492938 1.187 RNF43
ring finger protein 43
chr17_-_74483806 1.182 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr6_-_136847078 1.152 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr11_+_1860718 1.142 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr19_+_45281125 1.140 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr11_+_1860232 1.133 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr2_-_165424993 1.106 GRB14
growth factor receptor-bound protein 14
chr2_-_31352489 1.067 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr18_+_61254533 1.054 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr8_+_104831415 0.972 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr4_-_122302112 0.969 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr10_-_45474210 0.965 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr9_-_117156684 0.964 NM_030767
AKNA
AT-hook transcription factor
chr3_+_36421944 0.954 NM_003149
STAC
SH3 and cysteine rich domain
chr18_+_61554938 0.907 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_+_153003677 0.901 NM_003125
SPRR1B
small proline-rich protein 1B
chr3_+_186739643 0.844 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_47009992 0.838 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr1_+_152956563 0.827 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr12_+_44229851 0.815 NM_032256
TMEM117
transmembrane protein 117
chr1_-_116311398 0.810 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr3_+_189507448 0.806 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr1_-_153029987 0.805 NM_005988
SPRR2A
small proline-rich protein 2A
chrX_-_117119282 0.803 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr1_-_116311161 0.802 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116311330 0.784 CASQ2
calsequestrin 2 (cardiac muscle)
chr12_+_105153258 0.776 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr8_-_66701175 0.775 NM_002603
PDE7A
phosphodiesterase 7A
chr3_+_193853930 0.758 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr1_-_116383323 0.746 NM_001111061
NHLH2
nescient helix loop helix 2
chr17_+_7942351 0.744 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr17_-_3599359 0.735 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chrX_-_133792497 0.723 NM_021796
PLAC1
placenta-specific 1
chr3_+_111717585 0.696 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr1_+_44064509 0.690 PTPRF
protein tyrosine phosphatase, receptor type, F
chr21_-_42219038 0.688 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr2_+_103378489 0.685 NM_144632
TMEM182
transmembrane protein 182
chr19_+_20959109 0.679


chr16_+_57673206 0.673 NM_001145774
GPR56
G protein-coupled receptor 56
chr4_-_76944585 0.663 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr20_-_14318200 0.661 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr20_+_9288446 0.657 NM_000933
PLCB4
phospholipase C, beta 4
chr10_+_71561687 0.651 COL13A1
collagen, type XIII, alpha 1
chr19_+_15904760 0.645 NM_001004466
OR10H5
olfactory receptor, family 10, subfamily H, member 5
chr17_-_27467395 0.621 MYO18A
myosin XVIIIA
chr3_-_124842442 0.609 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr10_-_69425356 0.608 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr10_+_71561643 0.596 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr4_-_143767603 0.594 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr9_-_125941304 0.592 STRBP
spermatid perinuclear RNA binding protein
chr10_-_105845556 0.588 COL17A1
collagen, type XVII, alpha 1
chr1_+_152486977 0.586 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr10_+_82167584 0.584 NM_001243779
C10orf58
chromosome 10 open reading frame 58
chr1_-_204329043 0.582 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr1_+_26872306 0.560 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr8_+_103563847 0.551 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr1_+_92632608 0.547 NM_015237
KIAA1107
KIAA1107
chr17_-_39280377 0.546 NM_031854
KRTAP4-12
keratin associated protein 4-12
chr16_+_67233013 0.546 NM_024712
ELMO3
engulfment and cell motility 3
chr16_+_84328400 0.536 NM_021197
WFDC1
WAP four-disulfide core domain 1
chr1_+_77333158 0.525 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr1_-_153067000 0.523 NM_001024209
SPRR2E
small proline-rich protein 2E
chr4_+_89299874 0.520 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr6_+_26124372 0.513 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr8_-_42234562 0.510 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chrX_+_41548225 0.505 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr2_-_69180011 0.499 NM_182536
GKN2
gastrokine 2
chr3_+_127641901 0.494 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr12_+_41831484 0.492 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr10_+_111969988 0.488 NM_001008541
MXI1
MAX interactor 1
chr6_+_26158332 0.487 NM_021063
NM_138720
HIST1H2BD

histone cluster 1, H2bd

chr1_-_153013593 0.485 NM_006945
SPRR2D
small proline-rich protein 2D
chr4_-_40517913 0.485 NM_019027
RBM47
RNA binding motif protein 47
chr15_+_68908878 0.473 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr18_+_61442611 0.469 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr17_-_48945338 0.467 NM_001243877
TOB1
transducer of ERBB2, 1
chr1_-_242612757 0.466 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr8_-_38008332 0.466 NM_000349
STAR
steroidogenic acute regulatory protein
chr10_-_105845619 0.465 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr2_-_235405692 0.459 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr2_+_47596286 0.458 NM_002354
EPCAM
epithelial cell adhesion molecule
chr13_-_46756291 0.453 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr11_-_124190092 0.453 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr12_+_81101407 0.452 NM_002469
MYF6
myogenic factor 6 (herculin)
chr12_+_8975149 0.449 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr12_-_22094166 0.446 ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr3_+_193853937 0.444 HES1
hairy and enhancer of split 1, (Drosophila)
chr7_+_18535351 0.444 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr3_+_35683848 0.442 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chrX_-_77914824 0.432 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr1_+_77333121 0.430 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr2_+_106432922 0.430 NCK2
NCK adaptor protein 2
chr8_-_145642226 0.426 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr3_-_139258531 0.415 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr1_+_158223926 0.408 NM_001763
CD1A
CD1a molecule
chr14_-_53162418 0.403 NM_014584
ERO1L
ERO1-like (S. cerevisiae)
chr17_-_9694613 0.403 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr13_-_46756326 0.401 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr11_-_19223516 0.401 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr12_+_101188373 0.400 NM_178826
ANO4
anoctamin 4
chrX_-_49089770 0.398 NM_005183
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr20_-_46415277 0.396 NM_001161841
NM_198596
SULF2

sulfatase 2

chr2_-_148779172 0.396 NM_181742
ORC4
origin recognition complex, subunit 4
chr14_-_21493910 0.395 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr8_-_145642250 0.393 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr5_+_140165875 0.391 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr10_+_102758072 0.390 LZTS2
leucine zipper, putative tumor suppressor 2
chr1_-_217113007 0.389 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr14_-_21493858 0.387 NDRG2
NDRG family member 2
chr1_+_95558072 0.386 NM_001199679
TMEM56
transmembrane protein 56
chr4_-_110723334 0.381 NM_000204
CFI
complement factor I
chr5_+_140180782 0.381 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr11_-_85437457 0.374 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr10_+_695887 0.374 C10orf108
chromosome 10 open reading frame 108
chr14_-_23652840 0.373 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr22_+_45148437 0.372 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr12_+_21168629 0.365 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr13_-_52980628 0.365 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr17_+_18164423 0.362 NM_148886
SMCR7
Smith-Magenis syndrome chromosome region, candidate 7
chr11_-_118123001 0.361 NM_198275
MPZL3
myelin protein zero-like 3
chr5_-_83016850 0.358 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr8_-_86253863 0.357 NM_001164830
CA1
carbonic anhydrase I
chr15_+_94899163 0.354 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr6_+_132859426 0.352 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr12_+_55413728 0.352 NM_021191
NEUROD4
neurogenic differentiation 4
chr5_-_148442606 0.350 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr17_-_42200957 0.348 HDAC5
histone deacetylase 5
chr1_+_209878135 0.345 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr7_-_37488554 0.345 NM_014800
ELMO1
engulfment and cell motility 1
chr1_-_217262946 0.344 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr19_-_38747171 0.344 NM_001243947
NM_033256
PPP1R14A

protein phosphatase 1, regulatory (inhibitor) subunit 14A

chr2_-_165551178 0.344 COBLL1
COBL-like 1
chr15_+_42120155 0.342 NM_001114632
NM_001198588
NM_005090
JMJD7
JMJD7-PLA2G4B

jumonji domain containing 7
JMJD7-PLA2G4B readthrough

chr1_+_247581350 0.342 NM_001127462
NM_001243133
NM_004895
NM_183395
NLRP3



NLR family, pyrin domain containing 3



chr19_-_51487070 0.342 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr9_-_104145800 0.341 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr15_+_73976621 0.339 NM_001024736
NM_025240
CD276

CD276 molecule

chr18_-_53071225 0.339 NM_001243232
TCF4
transcription factor 4
chr4_+_88896838 0.336 SPP1
secreted phosphoprotein 1
chr21_-_36252872 0.336 RUNX1
runt-related transcription factor 1
chr21_-_39956823 0.336 NM_001243429
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr18_-_78005230 0.335 NM_032510
PARD6G
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr17_-_39728304 0.334 NM_000226
KRT9
keratin 9
chr13_-_46756295 0.331 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_+_7788094 0.329 NM_001005271
CHD3
chromodomain helicase DNA binding protein 3
chr5_-_142077508 0.328 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr4_+_103422479 0.324 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr17_-_42201009 0.322 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr12_-_86229981 0.317 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr21_+_30517897 0.315 C21orf7
chromosome 21 open reading frame 7
chr6_+_24357130 0.315 NM_181337
KAAG1
kidney associated antigen 1
chrX_-_63450486 0.315 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr14_-_103989112 0.311 CKB
creatine kinase, brain
chr12_+_52445185 0.310 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr10_-_69455926 0.305 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr5_-_142065586 0.301 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr15_+_80364902 0.301 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr1_+_145413190 0.300 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr6_+_37225506 0.298 NM_017772
TBC1D22B
TBC1 domain family, member 22B
chr2_-_241080072 0.297 NM_148961
OTOS
otospiralin
chr14_-_103988829 0.294 CKB
creatine kinase, brain
chr3_-_93747453 0.293 NM_001001850
STX19
syntaxin 19
chr5_+_121465214 0.293 NM_207317
ZNF474
zinc finger protein 474
chr1_+_175036993 0.292 NM_022093
TNN
tenascin N
chr2_-_190927321 0.292 NM_005259
MSTN
myostatin
chr5_-_35938736 0.289 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr14_-_23652818 0.289 SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chrX_-_24690740 0.288 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chrX_+_123234462 0.288 STAG2
stromal antigen 2
chr7_+_142982039 0.286 NM_001242773
NM_001242774
NM_001242775
NM_001242776
NM_001242777
NM_153345
TMEM139





transmembrane protein 139





chr4_-_110723127 0.285 CFI
complement factor I
chr6_+_14117486 0.276 NM_001251901
CD83
CD83 molecule
chr5_+_70944968 0.275 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr13_+_97928414 0.274 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_153085963 0.273 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr14_+_96722546 0.272 NM_000710
BDKRB1
bradykinin receptor B1
chr6_+_90604185 0.272 NM_032602
GJA10
gap junction protein, alpha 10, 62kDa
chr9_+_87284573 0.271 NM_001018065
NM_001018066
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr11_-_128894008 0.269 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr19_+_17862285 0.269 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr2_-_74007101 0.268 NM_003584
DUSP11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr17_-_41739261 0.267 NM_001040002
MEOX1
mesenchyme homeobox 1
chr11_+_64949391 0.267 CAPN1
calpain 1, (mu/I) large subunit
chr14_-_103989195 0.266 NM_001823
CKB
creatine kinase, brain
chr8_+_120079423 0.265 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.53 5.83e-03 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.83 2.55e-03 GO:0030016 myofibril
2.67 6.74e-03 GO:0043292 contractile fiber
2.64 1.85e-02 GO:0044449 contractile fiber part
2.74 2.62e-02 GO:0030017 sarcomere
5.80 3.34e-02 GO:0032982 myosin filament

Nothing significant found in function category.